CALCIPOTRIOL MONOHYDRATE

中文名	CALCIPOTRIOL MONOHYDRATE
英文名	CALCIPOTRIOL MONOHYDRATE
别名	卡泊三醇一水合物卡泊三醇单水合物钙泊三醇一水合物钙泊三醇一水合物 EP标准品卡泊三醇一水合物, 钙泊三醇一水合物
英文别名	CALCIPOTRIOL MONOHYDRATE Calcipotriol monohydrate CRS Calcipotriol (Calcipotriene) Monohydrate (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate
CAS	147657-22-5
EINECS	689-035-6
化学式	C27H40O3.H2O
分子量	430.625
溶解度	几乎不溶于水，易溶于乙醇 (96%)，微溶于二氯甲烷。
存储条件	-20℃
体外研究	When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH) 2 D 3 , Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH) 2 D 3 , Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation.
体内研究	One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model).

CALCIPOTRIOL MONOHYDRATE - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.322 ml	11.611 ml	23.222 ml
5 mM	0.464 ml	2.322 ml	4.644 ml
10 mM	0.232 ml	1.161 ml	2.322 ml
5 mM	0.046 ml	0.232 ml	0.464 ml

最后更新：2024-01-02 23:10:35

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